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Jeffrey A. Turk. Ph.D.

Associate Professor of Chemistry

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Education

     Post-doc - Purdue University, Lafayette, IN 2002-2004

     Ph.D. - University of Cincinnati, Cincinnati, OH 2002

     M.S. - University of Cincinnati, Cincinnati, OH 2001

     B.S. - Cleveland State University, Cleveland, OH 1997

Awards and Grant Support

     •   National Science Foundation ($150,000, funded 08/01/2009 - 07/31/2013)

              Title: “RUI: Synthesis and Evaluation of Group-1 Neuraminidase Inhibitors

     •     Faculty Travel Award ($300) awarded by ACS National Organic Symposium for travel to NOS (2009, Boulder, CO)

     •     Grant initiative program ($5000, 2010) - Title: “Synthesis of Sandalwood Odorants via Allene-Claisen Rearrangements”

                                                     ($5000, 2007) - Title: “Inhibition of the Avian Influenza Virus Neuraminidase (N1)”

     •     Faculty small grants ($600, 2014) - support for solid-phase synthesis

                                               ($600, 2010) - acquisition of SPME materials

                                               ($215, 2009) - In support of enzyme inhibitor project

                                               ($450, 2006, 2007, 2008) -In support of microwave assisted and fragrance ingredient synthesis

     •     University of Cincinnati Sponsored:     

               Lange fellowship (2001)

               Graduate student summer fellowship (2001)

               Excellence in duties as Senior Graduate Teaching Assistant (2001)

               Henry Hoschtetter Award for Excellence in Teaching (1998 and 1999)


Research Presentations by Undergraduate Students


“Group-1 Specific Neuraminidase Inhibitors Containing an Aromatic Scaffold” Cuthbertson, C. R.; Hanisko, J. M.; Kravat, A. J.; Turk, J. A.   244th ACS National Meeting; Philadelphia, PA. 2012. (poster)


“Di- and Tri-Substituted Aromatic Inhibitors of N1 Neuraminidase”, Monroe, A. J.; Gaudard, C. J.; Martinez, C.; Somers, B.; Turk, J. A.

     American Chemical Society, Midland Section (Alma, MI), October 2011. (oral)

     American Chemical Society, Midland Section (Alma, MI), October 2011. (poster)


“Neuraminidase, Transfections and Neuraminidase Inhibitors.”, Campbell, J.; Turk, J. A.; Beckmann, J. D.  PRISM Summer Research Symposium, Alma College, August 2011. (oral)


“Developing Recombinant N1 Neuraminidase”, Armstrong, R.; Turk, J. A.; Beckmann, J. D.  

     American Chemical Society, Midland Section (Alma, MI), October 2011, (oral)

     Honor’s Day, Alma College, April 2011. (oral)


"Design, Synthesis and Evaluation of Group-1 Specific Neuraminidase Inhibitors", Monroe, A. J.; Somers, B.; Turk, J. A.  Student Summer Research Symposium, Alma College, October 2010. (oral)


“Engineering the N1 Gene for Viral Neuraminidase Expression”, Armstrong, R.; Duymich, C.; Turk, J. A.; Beckmann, J. D. West Michigan Regional Undergraduate Science Research Conference (Grand Rapids, MI), October 2010. (poster)


"Design, Synthesis and Evaluation of Group-1 Specific Neuraminidase Inhibitors", Duymich, C.; Kallgren, J.; Turk, J. A.  

     Honor’s Day, Alma College, April 2009. (oral) Shared winners of Kapp prize.

     American Chemical Society Meeting (Midland, MI), October 2008. (poster)


"Sandalwoods via the Allene-Claisen Rearrangement", Reed, B.; Turk, J. A.  American Chemical Society Meeting (Midland, MI), October 2008. (poster) Winner of Best Undergraduate Poster.


"Synthesis and Evaluation of Group-1 Neuraminidase Inhibitors", Duymich, C.; Turk, J. A.  Student Summer Research Symposium, Alma College, September 2008. (oral)


"Sandalwoods via the Allene-Claisen Rearrangement", Reed, B.; Turk, J. A. Student Summer Research Symposium, Alma College, September 2008. (oral)


“Characterization of Trinitrophenylated Adenosine Nucleotide Binding to Bovine Phenol Sulfotransferase (bSULT1A1).”  Macdonald, J.A.; Sawin, A.; Lapham, D.; White, J.; Turk, J.A.; Beckmann, J.D. FASEB/American Society of Biochemistry and Molecular Biochemistry, 2008. (poster, collaboration with Dr. Beckmann)



Personal Research Presentations


“Design, Synthesis and Testing of Group-1 Specific Neuraminidase Inhibitors.” 244th ACS National Meeting; Philadelphia, PA. 2012. (oral)


“Drug Discovery at an Undergraduate Liberal Arts Institution.” ACS National Organic Symposium; Boulder, CO. 2009. (poster)


“Sandalwood:  More Than Just a Pleasant Smell.”  

     Olivet Nazarene University, Bourbonnais, IL.  April 2010. (invited lecture)

     Andrews University, Berrien Springs, MI. November 2009. (invited lecture)

     

“Drug Discovery at an Undergraduate Liberal Arts Institution.”  National Organic Symposium, June 2009. (poster)


“A Cure For The unCommon Bird Flu:  Neuraminidase Enzyme Inhibitors.”  Central Michigan Sigma Xi Spring banquet, April 2008. (invited lecture)


“Asymmetric Synthesis of All Diastereomers of 3-Hydroxy-2,4,6-trimethylheptanoic Acid”, 225th National ACS Meeting; New Orleans, LA., 2003. (poster)


"Synthetic Zinc Fingers:  A Stepwise Approach”

Graduate Student Research Scholarship Forum, University of Cincinnati, 2002. (poster)


“Synthesis and Conformational Analysis of β-Sheet Mimics That Contain a Hydrophobic Core”

     Cleveland State University, Dept. of Chemistry.  Cleveland, OH., 2001. (invited lecture)

       33rd Central/Great Lakes Joint Regional ACS meeting.  Grand Rapids, MI., 2001. (poster)

       221st ACS National Meeting.  San Diego, CA., 2001. (poster)

     Graduate Student Research Scholarship Forum. Univ. of Cincinnati., 2001. (poster)

       Oesper Symposium, University of Cincinnati, Cincinnati, OH., 2000, 2001. (poster)

“Protein Biomimetics:  Creating Synthetic β-Sheets”  Graduate Student Research/Scholarship Forum, University of Cincinnati, Cincinnati, OH., 2000. (poster)


“SACA Templates; Studying Protein Folding and Their Ability to Bind Amino Acids”  Oesper Symposium, University of Cincinnati, Cincinnati, OH., 1999. (poster)


“Developing Protein and Amino Acid Binders”  Oesper Symposium, University of Cincinnati, Cincinnati, OH., 1998. (poster)



Publications (* denotes undergraduates as co-authors)


Turk, J. A.; BeckmBeckman, J. D.  “Resources for an Investigative and Sustainable Undergraduate Medicinal Chemistry Program”  J. Chem.      Educ., 2012,      90, 137-139.


* Shubert, V. A.; Baquero, E. E.; Clarkson, J. R.; James, W. H. III; Turk, J. A.; Hare, A. A.; Morrel, K.; Lipton, M. A.; Schofield, D. P.; Jordan, K. D.; Zwier, T. S.  Entropy-driven population distributions in a prototypical molecule with two flexible side chains: O-(2-acetamidoethyl)-N-acetyltyramine.  J. Chem. Phys., 2007, 127, 234315. (I directed Alissa’s synthesis projects during my postdoctoral appointment at Purdue University.  Alissa was then in High School)


Krishnamoorthy, R.; Vazquez-Serrano, L. D.; Turk, J. A.; Kowalski, J. A.; Benson, A. G.; Breaux, N. T.; Lipton, M. A.  Solid-Phase Total Synthesis and Structure Proof of Callipeltin B.  J. Am. Chem. Soc., 2006, 128, 15392-15393.


Turk, J. A.; Visbal, G.; Lipton, M. A.  Asymmetric Synthesis of Four Diastereomers of 3-Hydroxy-2,4,6-Trimethylheptanoic acid:  Proof of Configurational Assignment.  J. Org. Chem., 2003, 68, 7841-7844.


Turk, J. A.; Smithrud, D.B.  Synthesis and Evaluation of Peptidomimetics that Bind DNA. Bioorg. Med. Chem., 2003, 11, 2355-2366.


Turk, J. A.; Smithrud, D.B.  Synthesis and Physical Properties of Protein Core Mimetics.  J. Org. Chem., 2001, 66, 8328-8335.


Duan, S.; Turk, J.; Spiegle, J.; Corbin, J.; Masnovi, J.; Baker, R. J.  Halogenations of Anthracenes and Dibenz[a,c]anthracene with N-Bromosuccinimide and N-Chlorosuccinimide.  J. Org. Chem., 2000, 65, 3005-3009.



Throughout graduate and postdoctoral studies, Professor Turk has gained extensive training in organic chemistry. While in graduate school at the University of Cincinnati, under the direction of Professor David B. Smithrud, he studied the design, synthesis and testing of molecules that recognized and bound DNA and protein surfaces. His doctoral dissertation is titled, "A Structure-Based Approach to Creating Synthetic Protein Mimetics that Bind DNA". During his last two years at UC, Professor Turk taught an Introduction to General, Organic, and Biochemistry course to health science majors. His postdoctoral research at Purdue University with Professor Mark A. Lipton refined his synthetic expertise while providing exposure to asymmetric chemistry, total synthesis and solid-phase organic/peptide synthesis. He also was co-director of the Combinatorial Library Synthesis Laboratory.


Following a two-year postdoctoral appointment at Purdue University, Professor Turk worked at C.B. Research and Development (now Adesis, Inc.), developing small molecule drug intermediates, and also worked as a research scientist at International Flavors and Fragrances, creating new aroma chemicals. After his short tenure in chemical industry, Professor Turk returned to academia and joined Alma College in 2006 as Assistant Professor of Chemistry.

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Office: KSC 246

(989) 463-7362

turk@alma.edu

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